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DSIP (Delta Sleep-Inducing Peptide)

Original price was: $29.99.Current price is: $22.99.

DSIP, or Delta Sleep-Inducing Peptide, is a naturally occurring neuropeptide first isolated from rabbit cerebral tissue. It is best known for its proposed role in regulating sleep architecture, particularly by promoting slow-wave (delta) sleep. Beyond its potential sleep-inducing effects, DSIP has been studied for its impact on stress modulation, hormonal balance, thermoregulation, and neuroprotection.

While its exact mechanisms remain under investigation, DSIP appears to influence several biological systems, including the hypothalamic-pituitary-adrenal (HPA) axis, GABAergic activity, and circadian rhythms. It is being researched for applications in sleep disorders, stress adaptation, and opioid withdrawal support.

Benefits:

Supports Deep, Restorative Sleep
Increases duration and quality of delta (slow-wave) sleep in animal studies.
Neuroprotective Properties
May reduce neuronal excitotoxicity and oxidative stress under certain lab conditions.
Modulates Cortisol and Stress Response
Affects the HPA axis, potentially reducing stress hormone spikes.
Normalizes Circadian Rhythms
May help regulate biological clock mechanisms in models of circadian disruption.
May Support Withdrawal Recovery
Studied for potential use in opioid or benzodiazepine detox protocols due to its calming properties.

Description

Clinical Evidence
  • A landmark study in Acta Physiologica Scandinavica (1977) demonstrated DSIP’s ability to induce delta sleep when administered intracerebroventricularly in rabbits.
  • DSIP has been shown to reduce stress-induced increases in ACTH and cortisol in rodent models (Peptides, 1986).
  • In models of ischemic brain injury, DSIP exhibited anti-apoptotic and anti-inflammatory effects, suggesting potential neuroprotective roles.
  • Some clinical experiments have noted improved sleep and reduced anxiety symptoms in small human cohorts, though findings remain preliminary.
  • DSIP’s wide-ranging actions across endocrine, neural, and metabolic pathways make it a versatile candidate for ongoing peptide research.

 

Potential Side Effects

DSIP has shown low toxicity and high tolerability in both animal and limited human studies. However, possible effects in research contexts include:

  • Mild sedation or drowsiness
  • Temporary changes in sleep cycles or vivid dreaming
  • Hypotension (rare and dose-dependent)
  • Headache or mild cognitive dulling (transient)
  • These effects are typically short-lived and dose-sensitive. DSIP does not appear to build dependence or tolerance in observed

 

Disclaimer

DSIP is for laboratory research use only. It is not approved for human consumption or therapeutic use. All data presented reflect findings from preclinical studies and exploratory human research. Use by qualified personnel in controlled laboratory environments only.

Additional information

MG

10

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