KPV is a synthetic tripeptide fragment derived from the C-terminal end of α-MSH (alpha-melanocyte-stimulating hormone). It is widely researched for its potent anti-inflammatory and immunomodulatory properties—particularly in models of gut inflammation, skin irritation, and immune overactivation.

Unlike the full α-MSH peptide, KPV exerts its therapeutic effects without stimulating melanogenesis (pigmentation). This makes it especially promising for inflammatory and autoimmune research, including applications in inflammatory bowel disease (IBD), dermatitis, and systemic inflammation. Its small size contributes to excellent tissue penetration and a favorable safety profile.

Benefits:

Potent Anti-Inflammatory Effects
Suppresses key inflammatory cytokines (e.g., TNF-α, IL-6, IL-1β) in multiple tissue types.
Reduces NF-κB Activation
Inhibits nuclear factor kappa B (NF-κB), a major transcription factor in inflammation.
Immunomodulatory Support
Helps restore immune balance without broadly suppressing immune function.
Supports Gut & Skin Health
Studied in colitis and dermatitis models for reducing inflammation and tissue damage.
Non-Melanogenic
Unlike other MSH-related peptides, KPV does not darken skin or affect melanocyte activity.
Topical, Oral, or Injectable Research Versatility
Effective in various delivery models, including topical gels, oral solutions, and injectable studies.