Name: Melanotan 1 (MT1)
SKU: 16085
Availability: InStock

Melanotan 1 (MT1)

Melanotan 1, also known as Afamelanotide, is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that binds selectively to the melanocortin 1 receptor (MC1R). It was developed for research into skin pigmentation, photoprotection, and UV damage reduction. Unlike Melanotan 2 (MT-2), MT-1 has a more targeted receptor profile and lacks strong sexual function effects, making it ideal for studies focused on melanogenesis and photoprotection.
Melanotan 1 has been approved in the EU and Australia under the brand name Scenesse® for treatment of erythropoietic protoporphyria (EPP), a rare disorder that causes extreme light sensitivity.

Benefits:

• Stimulates Natural Tanning
• Increases melanin production in the skin, potentially supporting UV protection and even pigmentation in research models.
• Photoprotective Effects
• Reduces UV-induced skin damage and oxidative stress by darkening the skin and possibly enhancing DNA repair mechanisms.
• Stable Receptor Selectivity
• Highly specific for MC1R, minimizing off-target effects associated with MT-2 (e.g., libido changes or appetite suppression).
• Low Immunogenicity
• Engineered for stability and reduced degradation in biological systems during research.
• Clinically Researched in Rare Light Sensitivity Disorders
• Used as a photoprotective treatment in clinical applications for disorders like EPP.

Description

Clinical Evidence

• Clinical trials published in The New England Journal of Medicine (2009) demonstrated that Afamelanotide significantly increased pain-free light exposure time in patients with EPP.
• Research has shown MT-1 to stimulate eumelanin production, the pigment type associated with deeper, UV-protective tanning.
• In photodamage models, MT-1 may reduce inflammatory cytokines and DNA damage markers caused by UVB exposure.
• Unlike MT-2, MT-1 lacks notable effects on MC3R/MC4R, minimizing systemic side effects.

Potential Side Effects

In preclinical and clinical studies, Melanotan 1 has shown a favorable safety profile. Reported side effects in research models may include:
• Injection site redness or irritation
• Mild nausea or fatigue
• Increased pigmentation in moles or freckles (typically reversible)
• Rare: darkening of existing skin lesions (important in dermatology research)
MT-1 appears to have fewer systemic effects than Melanotan 2, making it a cleaner candidate for pigmentation and UV-focused research.

Disclaimer

Melanotan 1 is for research use only. It is not approved for general human or veterinary use outside of approved pharmaceutical contexts (e.g., Scenesse® for EPP). All studies referenced are preclinical or regulatory-approved clinical trials. This product is intended strictly for use by trained professionals in controlled research settings.

Additional information

MG	10

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